Scientists have a unique touch to a long life to zero: an inherited mechanism of cellular repair, which prevents showing the process of aging and disease prevention, perhaps. Research say that the discovery could lead to anti-aging.
The study focuses on telomeres, the ends of chromosomes that have been sharp spikes to avoid plastic as compared to Come Undone. Telomeres were already known to play an important role in the aging process, and their discovery led to the Nobel Prize for medicine this year.
The new study, which focused on Ashkenazi Jews, who lived the longest of a hyperactive version of the telomerase, an enzyme that builds telomeres inherited.
Indeed, the centenarians in excellent mechanical equipment, body work 24 / 7 repair is likely that the functioning of the body, compared to a normal human cell Control Center, the body time to reflect over time.
"The man of exceptional longevity are in a better position to secure telomere length," said Yousin Suh, associate professor of medicine and genetics at the Albert Einstein College of Medicine at Yeshiva University. "And we found that they owe their longevity, at least partially, to advantageous variants of genes in telomere maintenance are involved."
The results were this week in Proceedings of the National Academy of Sciences.
Telomeres are short DNA fragments, which specialized chromosomes of the CAP, that tell a cell what to do. Over time, the cells divide again and again to keep the body alive. But shorten with each cell division, telomeres. If they are too short, the cell stops dividing and falls into a state called senescence. Vital tissue is no longer manufactured, and the organs begin to fail.
All this was known, and telomeres were the focus of research anti-aging for one year. However, it has not found a panacea, increasing the average life expectancy.
In the new study, Suh and colleagues studied Ashkenazi Jews, a homogeneous population, whose genetics are well studied. Three groups were part of the research: A very old (average age 97), but the group of 86 healthy people, 175 of their descendants, and a control group of 93 children of parents who have lived a normal life.
"Our research attempts to answer two questions," says researcher Gil Atzmon Einstein said in a statement. "Those who live longer tend to have long telomeres, and if so, could changes in the genes, on behalf of telomerase, telomeres for their time?
"Yes conclude" on both accounts, the researchers say.
The old man had mutated into "inherited genes that make the system more active and effective telomerase to maintain telomere length," write the researchers do. "Most of these people were spared cause age-related diseases such as cardiovascular disease and diabetes, that most deaths among the elderly.
"Our results suggest that length of telomeres and telomerase variants of genes that help people live longer, perhaps by linking them to diseases of old age we," said Suh. "Are you now trying to understand the mechanisms that maintain these genetic variants of telomerase, telomere length in centenarians. Finally, it can imitate blessed it for drugs, telomerase develop our centenarians were possible."
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